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Nutrient availability shapes methionine metabolism in p16/MTAP-deleted cells

Codeletions of gene loci containing tumor suppressors and neighboring metabolic enzymes present an attractive synthetic dependency in cancers. However, the impact that these genetic events have on metabolic processes, which are also dependent on nutrient availability and other environmental factors,...

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Publicat a:Sci Adv
Autors principals: Sanderson, Sydney M., Mikhael, Peter G., Ramesh, Vijyendra, Dai, Ziwei, Locasale, Jason W.
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594760/
https://ncbi.nlm.nih.gov/pubmed/31249865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav7769
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