Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing

AIMS: Statin-related myopathy (SRM), which includes rhabdomyolysis, is an uncommon but important adverse drug reaction because the number of people prescribed statins world-wide is large. Previous association studies of common genetic variants have had limited success in identifying a genetic basis...

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Published in:PLoS One
Main Authors: Floyd, James S., Bloch, Katarzyna M., Brody, Jennifer A., Maroteau, Cyrielle, Siddiqui, Moneeza K., Gregory, Richard, Carr, Daniel F., Molokhia, Mariam, Liu, Xiaoming, Bis, Joshua C., Ahmed, Ammar, Liu, Xuan, Hallberg, Pär, Yue, Qun-Ying, Magnusson, Patrik K. E., Brisson, Diane, Wiggins, Kerri L., Morrison, Alanna C., Khoury, Etienne, McKeigue, Paul, Stricker, Bruno H., Lapeyre-Mestre, Maryse, Heckbert, Susan R., Gallagher, Arlene M., Chinoy, Hector, Gibbs, Richard A., Bondon-Guitton, Emmanuelle, Tracy, Russell, Boerwinkle, Eric, Gaudet, Daniel, Conforti, Anita, van Staa, Tjeerd, Sitlani, Colleen M., Rice, Kenneth M., Maitland-van der Zee, Anke-Hilse, Wadelius, Mia, Morris, Andrew P., Pirmohamed, Munir, Palmer, Colin A. N., Psaty, Bruce M., Alfirevic, Ana
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594672/
https://ncbi.nlm.nih.gov/pubmed/31242253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0218115
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