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Kinetic analysis of transcellular passage of the cobalamin–transcobalamin complex in Caco-2 monolayers

We suggest a novel kinetic approach to quantifying receptor–ligand interactions via the cellular transport and/or accumulation of the ligand. The system of cobalamin (Cbl, vitamin B12) transport was used as a model, because Cbl is an obligatory cofactor, taken up by animal cells with the help of a t...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Juul, Christian B., Fedosov, Sergey N., Nexo, Ebba, Heegaard, Christian W.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594447/
https://ncbi.nlm.nih.gov/pubmed/30565973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-09-0571
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