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Self-assembled RNA-triple-helix hydrogel scaffold for microRNA modulation in the tumour microenvironment
The therapeutic potential of miRNA (miR) in cancer is limited by the lack of efficient delivery vehicles. Here, we show that a self-assembled dual-colour RNA-triple-helix structure comprising two miRNAs—a miR mimic (tumour suppressor miRNA) and an antagomiR (oncomiR inhibitor)—provides outstanding c...
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| Publicado no: | Nat Mater |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6594154/ https://ncbi.nlm.nih.gov/pubmed/26641016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmat4497 |
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