Expression of IL‐7Rα and KLRG1 defines functionally distinct CD8(+) T‐cell populations in humans

During acute viral infections in mice, IL‐7Rα and KLRG1 together are used to distinguish the short‐lived effector cells (SLEC; IL‐7Rα(lo)KLRG(hi)) from the precursors of persisting memory cells (MPEC; IL‐7Rα(hi)KLRG1(lo)). We here show that these markers can be used to define distinct subsets in the...

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Detalhes bibliográficos
Publicado no:Eur J Immunol
Main Authors: Remmerswaal, Ester B. M., Hombrink, Pleun, Nota, Benjamin, Pircher, Hanspeter, ten Berge, Ineke J. M., van Lier, René A. W., van Aalderen, Michiel C.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Adaptive immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593687/
https://ncbi.nlm.nih.gov/pubmed/30883723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201847897
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