Diosbulbin B-Induced Mitochondria-Dependent Apoptosis in L-02 Hepatocytes is Regulated by Reactive Oxygen Species-Mediated Autophagy

Aim: Diosbulbin B (DB) is a major diterpenoid compound found in Dioscorea bulbifera L, a traditional medicinal herb in China. Clinical reports have confirmed that Dioscorea bulbifera L. can induce significant hepatotoxicity. In this study, we showed that DB can induce mitochondria-dependent apoptosi...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Pharmacol
Auteurs principaux: Ye, Jing, Xue, Mei, Liu, Yamin, Zhu, Sirui, Li, Yu, Liu, Xiaoli, Cai, Danhong, Rui, Jia, Zhang, Liang
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593359/
https://ncbi.nlm.nih.gov/pubmed/31275148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00676
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