Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases

On-target, cell-active chemical probes are of fundamental importance in chemical and cell biology, whereas poorly characterized probes often lead to invalid conclusions. Human N-myristoyltransferase (NMT) has attracted increasing interest as target in cancer and infectious diseases. Here we report a...

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Pubblicato in:Cell Chem Biol
Autori principali: Kallemeijn, Wouter W., Lueg, Gregor A., Faronato, Monica, Hadavizadeh, Kate, Goya Grocin, Andrea, Song, Ok-Ryul, Howell, Michael, Calado, Dinis P., Tate, Edward W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593224/
https://ncbi.nlm.nih.gov/pubmed/31006618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.03.006
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