Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation

OBJECTIVE: Physiological mechanical loading reduces inflammatory signalling in numerous cell types including articular chondrocytes however the mechanism responsible remains unclear. This study investigates the role of chondrocyte primary cilia and associated intraflagellar transport (IFT) in the me...

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Publicado en:Osteoarthritis Cartilage
Main Authors: Fu, S., Thompson, C.L., Ali, A., Wang, W., Chapple, J.P., Mitchison, H.M., Beales, P.L., Wann, A.K.T., Knight, M.M.
Formato: Artigo
Idioma:Inglês
Publicado: W.B. Saunders For The Osteoarthritis Research Society 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593179/
https://ncbi.nlm.nih.gov/pubmed/30922983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2019.03.003
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