Blockade of myeloid differentiation 2 attenuates diabetic nephropathy by reducing activation of the renin‐angiotensin system in mouse kidneys

BACKGROUND AND PURPOSE: Both innate immunity and the renin‐angiotensin system (RAS) play important roles in the pathogenesis of diabetic nephropathy (DN). Myeloid differentiation factor 2 (MD2) is a co‐receptor of toll‐like receptor 4 (TLR4) in innate immunity. While TLR4 is involved in the developm...

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Библиографические подробности
Опубликовано в: :Br J Pharmacol
Главные авторы: Wang, Yi, Fang, Qilu, Jin, Yiyi, Liu, Zhoudi, Zou, Chunpeng, Yu, Weihui, Li, Weixin, Shan, Xiaoou, Chen, Ruijie, Khan, Zia, Liang, Guang
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2019
Предметы:
Research Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6592858/
https://ncbi.nlm.nih.gov/pubmed/30959575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14687
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