The Combination Rifampin-Nitazoxanide, but Not Rifampin-Isoniazid-Pyrazinamide-Ethambutol, Kills Dormant Mycobacterium tuberculosis in Hypoxia at Neutral pH

The activities of rifampin, nitazoxanide, PA-824, and sutezolid were tested against dormant Mycobacterium tuberculosis under conditions mimicking caseous granulomas (hypoxia at pH 7.3) in comparison with those of the combination rifampin-isoniazid-pyrazinamide-ethambutol (R-I-Z-E), which is used for...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Iacobino, Angelo, Giannoni, Federico, Pardini, Manuela, Piccaro, Giovanni, Fattorini, Lanfranco
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591638/
https://ncbi.nlm.nih.gov/pubmed/31010861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00273-19
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