Application of CRISPR/Cas9-Based Genome Editing in Studying the Mechanism of Pandrug Resistance in Klebsiella pneumoniae

In this study, a CRISPR/Cas9-mediated genome editing method was used to study the functions of the mgrB, tetA, and ramR genes in mediating colistin and tigecycline resistance in carbapenem-resistant Klebsiella pneumoniae (CRKP). Inactivation of the tetA or ramR gene or the mgrB gene by CRISPR/Cas9 a...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Sun, Qiaoling, Wang, Yu, Dong, Ning, Shen, Lingwei, Zhou, Hongwei, Hu, Yanyan, Gu, Danxia, Chen, Sheng, Zhang, Rong, Ji, Quanjiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591634/
https://ncbi.nlm.nih.gov/pubmed/30988149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00113-19
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