The Rheumatoid Arthritis Risk Gene AIRE Is Induced by Cytokines in Fibroblast-Like Synoviocytes and Augments the Pro-inflammatory Response

The autoimmune regulator AIRE controls the negative selection of self-reactive T-cells as well as the induction of regulatory T-cells in the thymus by mastering the transcription and presentation of tissue restricted antigens (TRAs) in thymic cells. However, extrathymic AIRE expression of hitherto u...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Bergström, Beatrice, Lundqvist, Christina, Vasileiadis, Georgios K., Carlsten, Hans, Ekwall, Olov, Ekwall, Anna-Karin H.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591464/
https://ncbi.nlm.nih.gov/pubmed/31275320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01384
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