Selective adrenergic alpha2C receptor antagonist ameliorates acute phencyclidine-induced schizophrenia-like social interaction deficits in rats

RATIONALE: Social withdrawal is a core feature of the negative symptoms of schizophrenia. Currently available pharmacotherapies have only limited efficacy towards the negative symptoms, i.e., there is a significant unmet medical need in the treatment of these symptoms. OBJECTIVE: We wanted to confir...

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Bibliographic Details
Published in:Psychopharmacology (Berl)
Main Authors: Savolainen, Katja, Ihalainen, Jouni, Jalkanen, Aaro J., Forsberg, Markus M.
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2018
Subjects:
Original Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591184/
https://ncbi.nlm.nih.gov/pubmed/30535904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-018-5130-2
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