Probing Protein Surfaces: QSAR Analysis using Helix Mimetics

α-helix mediated protein-protein interactions (PPIs) represent important targets for small molecule inhibition, however generic approaches to inhibitor design are in their infancy and would benefit from QSAR analyses to rationalize the non-covalent basis of molecular recognition by designed ligands....

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Bibliographische Detailangaben
Veröffentlicht in:Chembiochem
Hauptverfasser: Azzarito, Valeria, Rowell, Philip, Barnard, Anna, Edwards, Thomas A., Macdonald, Andrew, Warriner, Stuart L., Wilson, Andrew J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591138/
https://ncbi.nlm.nih.gov/pubmed/26690307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500504
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