Apical sodium-dependent bile acid transporter inhibition with volixibat improves metabolic aspects and components of non-alcoholic steatohepatitis in Ldlr-/-.Leiden mice

Interruption of bile acid recirculation through inhibition of the apical sodium-dependent bile acid transporter (ASBT) is a promising strategy to alleviate hepatic cholesterol accumulation in non-alcoholic steatohepatitis (NASH), and improve the metabolic aspects of the disease. Potential disease-at...

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Vydáno v:PLoS One
Hlavní autoři: Salic, Kanita, Kleemann, Robert, Wilkins-Port, Cynthia, McNulty, John, Verschuren, Lars, Palmer, Melissa
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590809/
https://ncbi.nlm.nih.gov/pubmed/31233523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0218459
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