Decreased RORC expression and downstream signaling in HTLV‐1‐associated adult T‐cell lymphoma/leukemia uncovers an antiproliferative IL17 link: A potential target for immunotherapy?

Retinoic acid‐related drugs have shown promising pre‐clinical activity in Adult T‐cell Leukemia/Lymphoma, but RORC signaling has not been explored. Therefore, we investigated transcriptome‐wide interactions of the RORC pathway in HTLV‐1 and ATL, using our own and publicly available gene expression d...

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Detalhes bibliográficos
Publicado no:Int J Cancer
Main Authors: Subramanian, Kritika, Dierckx, Tim, Khouri, Ricardo, Menezes, Soraya Maria, Kagdi, Huseini, Taylor, Graham P., Farre, Lourdes, Bittencourt, Achilea, Kataoka, Keisuke, Ogawa, Seishi, Van Weyenbergh, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2018
Assuntos:
Tumor Markers and Signatures
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590643/
https://ncbi.nlm.nih.gov/pubmed/30303535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.31922
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