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Influence of Renal Function on Evolocumab Exposure, Pharmacodynamics, and Safety
We evaluated the pharmacokinetics, pharmacodynamics, and safety of evolocumab, a fully human monoclonal antibody against proprotein convertase subtilisin kexin type 9 (PCSK9), in an open‐label, parallel‐design study in participants with normal renal function (n = 6), severe renal impairment (RI; n =...
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| Publicado no: | Clin Pharmacol Drug Dev |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6590207/ https://ncbi.nlm.nih.gov/pubmed/30676701 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.650 |
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