Pharmacologic Targeting of Red Blood Cells to Improve Tissue Oxygenation

Disruption of microvascular blood flow is a common cause of tissue hypoxia in disease, yet no therapies are available that directly target the microvasculature to improve tissue oxygenation. Red blood cells (RBCs) autoregulate blood flow through S-nitroso-hemoglobin (SNO-Hb)-mediated export of nitri...

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Bibliografische gegevens
Gepubliceerd in:Clin Pharmacol Ther
Hoofdauteurs: Reynolds, James D., Jenkins, Trevor, Matto, Faisal, Nazemian, Ryan, Farhan, Obada, Morris, Nathan, Longphre, John M., Hess, Douglas T., Moon, Richard E., Piantadosi, Claude A., Stamler, Jonathan S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590078/
https://ncbi.nlm.nih.gov/pubmed/29238951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.979
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