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Mechanism of Microbicidal Action of E-101 Solution, a Myeloperoxidase-Mediated Antimicrobial, and Its Oxidative Products

E-101 solution is a first-in-class myeloperoxidase-mediated antimicrobial developed for topical application. It is composed of porcine myeloperoxidase (pMPO), glucose oxidase (GO), glucose, sodium chloride, and specific amino acids in an aqueous solution. Once activated, the reactive species hydroge...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Denys, Gerald A., Devoe, Neil C., Gudis, Polyxeni, May, Meghan, Allen, Robert C., Stephens, Jackson T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589053/
https://ncbi.nlm.nih.gov/pubmed/31010816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00261-19
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