An increased rate of longitudinal cognitive decline is observed in Parkinson’s disease patients with low CSF Aß42 and an APOE ε4 allele

OBJECTIVE: Low concentrations of cerebrospinal fluid (CSF) amyloid-beta (Aβ-42) are associated with increased risk of cognitive decline in Parkinson’s disease (PD). We sought to determine whether APOE genotype modifies the rate of cognitive decline in PD patients with low CSF Aβ-42 compared to patie...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Shahid, Marian, Kim, Jeehyun, Leaver, Katherine, Hendershott, Taylor, Zhu, Delphine, Cholerton, Brenna, Henderson, Victor W, Tian, Lu, Poston, Kathleen L
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588475/
https://ncbi.nlm.nih.gov/pubmed/30826425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.02.023
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