The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in Wilms tumour development and human nephrogenesis

Wilms tumour is a paediatric malignancy with features of halted kidney development. Here, we demonstrate that the Iroquois homeobox genes IRX3 and IRX5 are essential for mammalian nephrogenesis and govern the differentiation of Wilms tumour. Knock‐out Irx3 (−) /Irx5 (−) mice showed a strongly reduce...

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Detaylı Bibliyografya
Yayımlandı:J Pathol
Asıl Yazarlar: Holmquist Mengelbier, Linda, Lindell‐Munther, Simon, Yasui, Hiroaki, Jansson, Caroline, Esfandyari, Javanshir, Karlsson, Jenny, Lau, Kimberly, Hui, Chi‐chung, Bexell, Daniel, Hopyan, Sevan, Gisselsson, David
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley & Sons, Ltd 2018
Konular:
Original Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588170/
https://ncbi.nlm.nih.gov/pubmed/30246301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5171
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