Highly sensitive and rapid determination of tacrolimus in peripheral blood mononuclear cells by liquid chromatography–tandem mass spectrometry

After solid organ transplantation, tacrolimus is given to prevent rejection. Therapeutic drug monitoring is used to reach target concentrations of tacrolimus in whole blood. Because the site of action of tacrolimus is the lymphocyte, and tacrolimus binds ~80% to erythrocytes, the intracellular tacro...

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Detaylı Bibliyografya
Yayımlandı:Biomed Chromatogr
Asıl Yazarlar: Bahmany, Soma, de Wit, Lucia E.A., Hesselink, Dennis A., van Gelder, Teun, Shuker, Nauras M., Baan, Carla, van der Nagel, Bart C.H., Koch, Birgit C.P., de Winter, Brenda C.M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2018
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587946/
https://ncbi.nlm.nih.gov/pubmed/30362145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bmc.4416
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