Highly sensitive and rapid determination of tacrolimus in peripheral blood mononuclear cells by liquid chromatography–tandem mass spectrometry

After solid organ transplantation, tacrolimus is given to prevent rejection. Therapeutic drug monitoring is used to reach target concentrations of tacrolimus in whole blood. Because the site of action of tacrolimus is the lymphocyte, and tacrolimus binds ~80% to erythrocytes, the intracellular tacro...

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Detalhes bibliográficos
Publicado no:Biomed Chromatogr
Main Authors: Bahmany, Soma, de Wit, Lucia E.A., Hesselink, Dennis A., van Gelder, Teun, Shuker, Nauras M., Baan, Carla, van der Nagel, Bart C.H., Koch, Birgit C.P., de Winter, Brenda C.M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587946/
https://ncbi.nlm.nih.gov/pubmed/30362145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bmc.4416
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