The quaternary structure of human tyrosine hydroxylase: effects of dystonia‐associated missense variants on oligomeric state and enzyme activity

ABSTRACT: Tyrosine hydroxylase (TH) is a multi‐domain, homo‐oligomeric enzyme that catalyses the rate‐limiting step of catecholamine neurotransmitter biosynthesis. Missense variants of human TH are associated with a recessive neurometabolic disease with low levels of brain dopamine and noradrenaline...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Neurochem
Main Authors: Szigetvari, Peter D., Muruganandam, Gopinath, Kallio, Juha P., Hallin, Erik I., Fossbakk, Agnete, Loris, Remy, Kursula, Inari, Møller, Lisbeth B., Knappskog, Per M., Kursula, Petri, Haavik, Jan
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2018
Assuntos:
ORIGINAL ARTICLES
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587854/
https://ncbi.nlm.nih.gov/pubmed/30411798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.14624
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares