The quaternary structure of human tyrosine hydroxylase: effects of dystonia‐associated missense variants on oligomeric state and enzyme activity

ABSTRACT: Tyrosine hydroxylase (TH) is a multi‐domain, homo‐oligomeric enzyme that catalyses the rate‐limiting step of catecholamine neurotransmitter biosynthesis. Missense variants of human TH are associated with a recessive neurometabolic disease with low levels of brain dopamine and noradrenaline...

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Vydáno v:J Neurochem
Hlavní autoři: Szigetvari, Peter D., Muruganandam, Gopinath, Kallio, Juha P., Hallin, Erik I., Fossbakk, Agnete, Loris, Remy, Kursula, Inari, Møller, Lisbeth B., Knappskog, Per M., Kursula, Petri, Haavik, Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
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ORIGINAL ARTICLES
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587854/
https://ncbi.nlm.nih.gov/pubmed/30411798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.14624
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