Spectroscopic detection of brain propylene glycol in neonates: Effects of different pharmaceutical formulations of phenobarbital

BACKGROUND: The first choice for treatment of neonatal convulsions is intravenous phenobarbital, which contains propylene glycol (PG) as a solvent. Although PG is generally considered safe, the dosage can exceed safety thresholds in neonates. High PG levels can cause lactic acidosis. PURPOSE/HYPOTHE...

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Bibliografiske detaljer
Udgivet i:J Magn Reson Imaging
Main Authors: Pouwels, Petra J.W., van de Lagemaat, Monique, van de Pol, Laura A., Witjes, Bregje C.M., Zonnenberg, Inge A.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587756/
https://ncbi.nlm.nih.gov/pubmed/30350475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jmri.26344
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