Aneuploid acute myeloid leukemia exhibits a signature of genomic alterations in the cell cycle and protein degradation machinery

BACKGROUND: Aneuploidy occurs in more than 20% of acute myeloid leukemia (AML) cases and correlates with an adverse prognosis. METHODS: To understand the molecular bases of aneuploid acute myeloid leukemia (A‐AML), this study examined the genomic profile in 42 A‐AML cases and 35 euploid acute myeloi...

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Detalhes bibliográficos
Publicado no:Cancer
Main Authors: Simonetti, Giorgia, Padella, Antonella, do Valle, Italo Farìa, Fontana, Maria Chiara, Fonzi, Eugenio, Bruno, Samantha, Baldazzi, Carmen, Guadagnuolo, Viviana, Manfrini, Marco, Ferrari, Anna, Paolini, Stefania, Papayannidis, Cristina, Marconi, Giovanni, Franchini, Eugenia, Zuffa, Elisa, Laginestra, Maria Antonella, Zanotti, Federica, Astolfi, Annalisa, Iacobucci, Ilaria, Bernardi, Simona, Sazzini, Marco, Ficarra, Elisa, Hernandez, Jesus Maria, Vandenberghe, Peter, Cools, Jan, Bullinger, Lars, Ottaviani, Emanuela, Testoni, Nicoletta, Cavo, Michele, Haferlach, Torsten, Castellani, Gastone, Remondini, Daniel, Martinelli, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6587451/
https://ncbi.nlm.nih.gov/pubmed/30480765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.31837
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