Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption after ischemic stroke

Endothelium (EC) is a key component of blood–brain barrier (BBB), and has an important position in the neurovascular unit. Its dysfunction and death after cerebral ischemic/reperfusion (I/R) injury not only promote evolution of neuroinflammation and brain edema, but also increase the risk of intrace...

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Dades bibliogràfiques
Publicat a:Cell Death Dis
Autors principals: Chen, An-Qi, Fang, Zhi, Chen, Xiao-Lu, Yang, Shuai, Zhou, Yi-Fan, Mao, Ling, Xia, Yuan-Peng, Jin, Hui-Juan, Li, Ya-Nan, You, Ming-Feng, Wang, Xu-Xia, Lei, Hao, He, Quan-Wei, Hu, Bo
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586814/
https://ncbi.nlm.nih.gov/pubmed/31221990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1716-9
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