Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation

The different stages of the metastatic cascade present distinct metabolic challenges to tumour cells and an altered tumour metabolism associated with successful metastatic colonisation provides a therapeutic vulnerability in disseminated disease. We identify the aldo-keto reductase AKR1B10 as a meta...

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Udgivet i:Nat Commun
Main Authors: van Weverwijk, Antoinette, Koundouros, Nikolaos, Iravani, Marjan, Ashenden, Matthew, Gao, Qiong, Poulogiannis, George, Jungwirth, Ute, Isacke, Clare M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586667/
https://ncbi.nlm.nih.gov/pubmed/31221959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10592-4
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