Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation

The different stages of the metastatic cascade present distinct metabolic challenges to tumour cells and an altered tumour metabolism associated with successful metastatic colonisation provides a therapeutic vulnerability in disseminated disease. We identify the aldo-keto reductase AKR1B10 as a meta...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: van Weverwijk, Antoinette, Koundouros, Nikolaos, Iravani, Marjan, Ashenden, Matthew, Gao, Qiong, Poulogiannis, George, Jungwirth, Ute, Isacke, Clare M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586667/
https://ncbi.nlm.nih.gov/pubmed/31221959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10592-4
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