Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis

Hepatic steatosis develops when lipid influx and production exceed the liver’s ability to utilize/export triglycerides. Obesity promotes steatosis and is characterized by leptin resistance. A role of leptin in hepatic lipid handling is highlighted by the observation that recombinant leptin reverses...

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Vydáno v:Nat Commun
Hlavní autoři: Hackl, Martina Theresa, Fürnsinn, Clemens, Schuh, Christina Maria, Krssak, Martin, Carli, Fabrizia, Guerra, Sara, Freudenthaler, Angelika, Baumgartner-Parzer, Sabina, Helbich, Thomas H., Luger, Anton, Zeyda, Maximilian, Gastaldelli, Amalia, Buettner, Christoph, Scherer, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586634/
https://ncbi.nlm.nih.gov/pubmed/31222048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10684-1
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