Fibrostenotic eosinophilic esophagitis may reflect epithelial lysyl oxidase induction by fibroblasts-derived tumor necrosis factor-α

BACKGROUND: Fibrosis and stricture are major comorbidities in eosinophilic esophagitis (EoE). Lysyl oxidase (LOX), a collagen cross-linking enzyme, has not been investigated in the context of EoE. OBJECTIVE: We investigated regulation of epithelial LOX expression as a novel biomarker and functional...

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Опубликовано в: :J Allergy Clin Immunol
Главные авторы: Kasagi, Yuta, Dods, Kara, Wang, Joshua X., Chandramouleeswaran, Prasanna M, Benitez, Alain J., Gambanga, Fiona, Kluger, Jonathan, Ashorobi, Tokunbo, Gross, Jonathan, Tobias, John W., Klein-Szanto, Andres J., Spergel, Jonathan M., Cianferoni, Antonella, Falk, Gary W., Whelan, Kelly A., Nakagawa, Hiroshi, Muir, Amanda B.
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586527/
https://ncbi.nlm.nih.gov/pubmed/30578874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2018.10.067
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