Synthesis and biological evaluation of novel 8-substituted quinoline-2-carboxamides as carbonic anhydrase inhibitors

A series of novel 8-substituted-N-(4-sulfamoylphenyl)quinoline-2-carboxamides was synthesised by the reaction of 8-hydroxy-N-(4-sulfamoylphenyl) quinoline-2-carboxamide with alkyl and benzyl halides. The compounds were assayed for carbonic anhydrase (CA) inhibitory activity against four hCA isoforms...

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Detalles Bibliográficos
Publicado en:J Enzyme Inhib Med Chem
Autores principales: Thacker, Pavitra S., Shaikh, Pirpasha, Angeli, Andrea, Arifuddin, Mohammed, Supuran, Claudiu T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586119/
https://ncbi.nlm.nih.gov/pubmed/31218888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1626376
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