Iron refractory iron deficiency anemia: a heterogeneous disease that is not always iron refractory

TMPRSS6 variants that affect protein function result in impaired matriptase‐2 function and consequently uninhibited hepcidin production, leading to iron refractory iron deficiency anemia (IRIDA). This disease is characterized by microcytic, hypochromic anemia and serum hepcidin values that are inapp...

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Vydáno v:Am J Hematol
Hlavní autoři: Donker, Albertine E., Schaap, Charlotte C.M., Novotny, Vera M. J., Smeets, Roel, Peters, Tessa M. A., van den Heuvel, Bert L. P., Raphael, Martine F., Rijneveld, Anita W., Appel, Inge M., Vlot, Andre J., Versluijs, A. Birgitta, van Gelder, Michel, Granzen, Bernd, Janssen, Mirian C.H., Rennings, Alexander J.M., van de Veerdonk, Frank L., Brons, Paul P.T., Bakkeren, Dirk L., Nijziel, Marten R., Vlasveld, L. Thom, Swinkels, Dorine W.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586001/
https://ncbi.nlm.nih.gov/pubmed/27643674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.24561
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