Substitution of lysine for isoleucine at the center of the nonpolar face of the antimicrobial peptide, piscidin-1, leads to an increase in the rapidity of bactericidal activity and a reduction in toxicity

Purpose: Piscidin-1 is an effective antimicrobial peptide (AMP) against a variety of microbes. However, its toxicity has been reported as a limitation for its potential therapeutic applications. The toxicity of piscidin-1 may be related to the long nonpolar face of this AMP. Here, we investigated di...

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Bibliografiske detaljer
Udgivet i:Infect Drug Resist
Main Authors: Taheri, Behrouz, Mohammadi, Mohsen, Momenzadeh, Niloofar, Farshadzadeh, Zahra, Roozbehani, Mona, Dehghani, Parva, Hajian, Sobhan, Darvishi, Sadegh, Shamseddin, Jebreil
Format: Artigo
Sprog:Inglês
Udgivet: Dove 2019
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6585414/
https://ncbi.nlm.nih.gov/pubmed/31354312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IDR.S195872
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