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TPP1 Delivery to Lysosomes with Extracellular Vesicles and their Enhanced Brain Distribution in the Animal Model of Batten Disease

Extracellular vesicles (EVs) are promising natural nanocarriers for delivery of various types of therapeutics. Earlier engineered EV-based formulations for neurodegenerative diseases and cancer are reported. Herein, the use of macro-phage-derived EVs for brain delivery of a soluble lysosomal enzyme...

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Detalhes bibliográficos
Publicado no:Adv Healthc Mater
Main Authors: Haney, Matthew J., Klyachko, Natalia L., Harrison, Emily B., Zhao, Yuling, Kabanov, Alexander V., Batrakova, Elena V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6584948/
https://ncbi.nlm.nih.gov/pubmed/30997751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201801271
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