Natural Immunity to HIV is associated with Low BLyS/BAFF levels and low frequencies of innate marginal zone like CD1c(+) B-cells in the genital tract

BLyS/BAFF is recognized for its role in B-cell ontogenesis, as well as cell fate decision towards the first-line/innate marginal zone (MZ) B-cell pool. Excess BLyS/BAFF is associated with hyperglobulinemia and increased frequencies of activated precursor-like MZ B-cells. Herein, we show that HIV hig...

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Détails bibliographiques
Publié dans:PLoS Pathog
Auteurs principaux: Fourcade, Lyvia, Sabourin-Poirier, Catherine, Perraud, Victoire, Faucher, Marie-Claude, Chagnon-Choquet, Josiane, Labbé, Annie-Claude, Alary, Michel, Guédou, Fernand, Poudrier, Johanne, Roger, Michel
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6583986/
https://ncbi.nlm.nih.gov/pubmed/31173604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007840
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