Effect of Cell-Free DNA Screening vs Direct Invasive Diagnosis on Miscarriage Rates in Women With Pregnancies at High Risk of Trisomy 21: A Randomized Clinical Trial

IMPORTANCE: Cell-free DNA (cfDNA) tests are increasingly being offered to women in the first trimester of pregnancies at a high risk of trisomy 21 to decrease the number of required invasive fetal karyotyping procedures and their associated miscarriages. The effect of this strategy has not been eval...

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Dettagli Bibliografici
Pubblicato in:JAMA
Autori principali: Malan, Valérie, Bussières, Laurence, Winer, Norbert, Jais, Jean-Philippe, Baptiste, Amandine, Le Lorc’h, Marc, Elie, Caroline, O’Gorman, Neil, Fries, Nicolas, Houfflin-Debarge, Véronique, Sentilhes, Loic, Vekemans, Michel, Ville, Yves, Salomon, Laurent J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Medical Association 2018
Soggetti:
Original Investigation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6583003/
https://ncbi.nlm.nih.gov/pubmed/30120476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2018.9396
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