The Orai Ca(2+) channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis

Key features of acute pancreatitis include excess cellular Ca(2+) entry driven by Ca(2+) depletion from the endoplasmic reticulum (ER) and subsequent activation of store-operated Ca(2+) entry (SOCE) channels in the plasma membrane. In several cell types including pancreatic acinar, stellate cells (P...

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Publicat a:J Physiol
Autors principals: Waldron, Richard T., Chen, Yafeng, Pham, Hung, Go, Ariel, Su, Hsin-Yuan, Hu, Cheng, Wen, Li, Husain, Sohail Z., Sugar, Catherine A., Roos, Jack, Ramos, Stephanie, Lugea, Aurelia, Dunn, Michael, Stauderman, Kenneth, Pandol, Stephen J.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582954/
https://ncbi.nlm.nih.gov/pubmed/31050811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP277856
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