Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids

OBJECTIVE: Aldehyde dehydrogenase 2 (ALDH2), a key enzyme to detoxify acetaldehyde in the liver, exists in both active and inactive forms in humans. Individuals with inactive ALDH2 accumulate acetaldehyde after alcohol consumption. However, how acetaldehyde affects T-cell hepatitis remains unknown....

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Detalles Bibliográficos
Publicado en:Gut
Autores principales: Gao, Yanhang, Zhou, Zhou, Ren, Tianyi, Kim, Seung-Jin, He, Yong, Seo, Wonhyo, Guillot, Adrien, Ding, Yanhua, Wu, Ruihong, Shao, Shuang, Wang, Xiaomei, Zhang, Hong, Wang, Wei, Feng, Dechun, Xu, Mingjiang, Han, Elaine, Zhong, Wei, Zhou, Zhanxiang, Pacher, Pal, Niu, Junqi, Gao, Bin
Formato: Artigo
Lenguaje:Inglês
Publicado: BMJ Publishing Group 2019
Materias:
Hepatology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582747/
https://ncbi.nlm.nih.gov/pubmed/30121625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2018-316221
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