Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer

Macrophages play an important role in regulating the tumor microenvironment (TME). Here we show that classical (M1) macrophage polarization reduced expression of LSD1, nuclear REST corepressor 1 (CoREST), and the zinc finger protein SNAIL. The LSD1 inhibitor phenelzine targeted both the flavin adeni...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Tan, Abel H. Y., Tu, WenJuan, McCuaig, Robert, Hardy, Kristine, Donovan, Thomasina, Tsimbalyuk, Sofiya, Forwood, Jade K., Rao, Sudha
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582666/
https://ncbi.nlm.nih.gov/pubmed/31249575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01351
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