Bioorthogonal Fluorescence Turn‐On Labeling Based on Bicyclononyne−Tetrazine Cycloaddition Reactions that Form Pyridazine Products

Fluorogenic bioorthogonal reactions enable visualization of biomolecules with excellent signal‐to‐noise ratio. A bicyclononyne−tetrazine ligation that produces fluorescent pyridazine products has been developed. In stark contrast to previous approaches, the formation of the dye is an inherent result...

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Bibliographic Details
Published in:Chempluschem
Main Authors: Siegl, Sebastian J., Galeta, Juraj, Dzijak, Rastislav, Dračínský, Martin, Vrabel, Milan
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
Subjects:
Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582594/
https://ncbi.nlm.nih.gov/pubmed/31245251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cplu.201900176
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