Multiple independent L-gulonolactone oxidase (GULO) gene losses and vitamin C synthesis reacquisition events in non-Deuterostomian animal species

BACKGROUND: L-ascorbate (Vitamin C) is an important antioxidant and co-factor in eukaryotic cells, and in mammals it is indispensable for brain development and cognitive function. Vertebrates usually become L-ascorbate auxothrophs when the last enzyme of the synthetic pathway, an L-gulonolactone oxi...

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Publicado en:BMC Evol Biol
Autores principales: Henriques, Sílvia F., Duque, Pedro, López-Fernández, Hugo, Vázquez, Noé, Fdez-Riverola, Florentino, Reboiro-Jato, Miguel, Vieira, Cristina P., Vieira, Jorge
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582580/
https://ncbi.nlm.nih.gov/pubmed/31215418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12862-019-1454-8
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