Regulation and role of the ER stress transcription factor CHOP in alveolar epithelial type-II cells

ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by type-II alveolar epithelial cell (AECII) injury and fibroblast hyperproliferation. Severe AECII endoplasmic reticulum (ER) stress is thought to underlie IPF, but is yet incompletely understood. We studied the regulatio...

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Bibliografiske detaljer
Udgivet i:J Mol Med (Berl)
Main Authors: Klymenko, Oleksiy, Huehn, Martin, Wilhelm, Jochen, Wasnick, Roxana, Shalashova, Irina, Ruppert, Clemens, Henneke, Ingrid, Hezel, Stefanie, Guenther, Katharina, Mahavadi, Poornima, Samakovlis, Christos, Seeger, Werner, Guenther, Andreas, Korfei, Martina
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2019
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581940/
https://ncbi.nlm.nih.gov/pubmed/31025089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-019-01787-9
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