Regulation of Diabetogenic Immunity by IL15-activated Regulatory CD8 T cells in Type 1 Diabetes

Unchecked collaboration between islet-reactive T and B lymphocytes drives Type 1 Diabetes (T1D). In the healthy setting, CD8 T Regulatory Cells (CD8 Tregs) terminate ongoing T-B interactions. We determined that specific CD8 Tregs from Non-obese Diabetic (NOD) mice lack suppressive function, represen...

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Bibliographic Details
Published in:J Immunol
Main Authors: Stocks, Blair T., Wilson, Christopher S., Marshall, Andrew F., Hoopes, Emilee M., Moore, Daniel J.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581590/
https://ncbi.nlm.nih.gov/pubmed/31127035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800976
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