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The chemical synthesis of the R(p) and S(p) diastereomers of uridyl (3′-5′) adenyl O,O-phosphorothioate
A procedure is described for the synthesis of the title compounds via phosphotriester intermediates. The 2-cyanoethyl group is used to protect the P-SH function during the course of the synthesis. Resolution of the phosphorus-diastereomers is accomplished at the phosphotriester stage. Removal of the...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
1978
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6581369/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/1.suppl_1.s43 |
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