Clopidogrel Pharmacogenetics: State of the Art Review and the TAILOR-PCI Study

Common genetic variation in CYP2C19 (*2 and *3 alleles) leads to a loss of functional protein and carriers of these loss-of-function alleles when treated with clopidogrel have significantly reduced clopidogrel-active metabolite levels and high on-treatment platelet reactivity resulting in increased...

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Gepubliceerd in:Circ Cardiovasc Interv
Hoofdauteurs: Pereira, Naveen L., Rihal, Charanjit S., So, Derek, Rosenberg, Yves, Lennon, Ryan J., Mathew, Verghese, Goodman, Shaun, Weinshilboum, Richard M., Wang, Liewei, Baudhuin, Linnea M., Lerman, Amir, Hasan, Ahmed, Iturriaga, Erin, Fu, Yi-Ping, Geller, Nancy, Bailey, Kent, Farkouh, Michael
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581205/
https://ncbi.nlm.nih.gov/pubmed/30998396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.007811
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