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Robust optimization for intensity‐modulated proton therapy with soft spot sensitivity regularization

PURPOSE: Proton dose distribution is sensitive to uncertainties in range estimation and patient positioning. Currently, the proton robustness is managed by worst‐case scenario optimization methods, which are computationally inefficient. To overcome these challenges, we develop a novel intensity‐modu...

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Vydáno v:Med Phys
Hlavní autoři: Gu, Wenbo, Ruan, Dan, O'Connor, Daniel, Zou, Wei, Dong, Lei, Tsai, Min‐Yu, Jia, Xun, Sheng, Ke
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581199/
https://ncbi.nlm.nih.gov/pubmed/30570164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mp.13344
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