Neurite orientation and dispersion density imaging (NODDI) detects cortical and corticospinal tract degeneration in ALS

BACKGROUND: Corticospinal tract (CST) degeneration and cortical atrophy are consistent features of amyotrophic lateral sclerosis (ALS). We hypothesised that neurite orientation dispersion and density imaging (NODDI), a multicompartment model of diffusion MRI, would reveal microstructural changes ass...

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Detalhes bibliográficos
Publicado no:J Neurol Neurosurg Psychiatry
Main Authors: Broad, Rebecca J, Gabel, Matt C, Dowell, Nicholas G, Schwartzman, David J, Seth, Anil K, Zhang, Hui, Alexander, Daniel C, Cercignani, Mara, Leigh, P Nigel
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2019
Assuntos:
Neurodegeneration
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581155/
https://ncbi.nlm.nih.gov/pubmed/30361295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp-2018-318830
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