Beta-binomial modeling of CRISPR pooled screen data identifies target genes with greater sensitivity and fewer false negatives

The simplicity and cost-effectiveness of CRISPR technology have made high-throughput pooled screening approaches accessible to virtually any laboratory. Analyzing the large sequencing data derived from these studies, however, still demands considerable bioinformatics expertise. Various methods have...

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Bibliographic Details
Published in:Genome Res
Main Authors: Jeong, Hyun-Hwan, Kim, Seon Young, Rousseaux, Maxime W.C., Zoghbi, Huda Y., Liu, Zhandong
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2019
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Method
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581060/
https://ncbi.nlm.nih.gov/pubmed/31015259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.245571.118
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