Subclinical Cytomegalovirus DNA Is Associated with CD4 T Cell Activation and Impaired CD8 T Cell CD107a Expression in People Living with HIV despite Early Antiretroviral Therapy

Most people living with HIV (PLWH) are coinfected with cytomegalovirus (CMV). Subclinical CMV replication is associated with immune dysfunction and with increased HIV DNA in antiretroviral therapy (ART)-naive and -suppressed PLWH. To identify immunological mechanisms by which CMV could favor HIV per...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Christensen-Quick, Aaron, Massanella, Marta, Frick, Andrew, Rawlings, Stephen A., Spina, Celsa, Vargas-Meneses, Milenka, Schrier, Rachel, Nakazawa, Masato, Anderson, Christy, Gianella, Sara
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580967/
https://ncbi.nlm.nih.gov/pubmed/31019052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00179-19
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