Melibiosamine, a novel oligosaccharide, suppresses mitogen-induced IL-2 production via inactivation of NFAT and NFκB in Jurkat cells

d-Glucosamine (GlcNH(2)) and several of its derivatives are known to possess immunosuppressive activities in various immune cell lines. The novel GlcNH(2)-containing oligosaccharide Galα1-6GlcNH(2) (designated melibiosamine; MelNH(2)) is expected to be immunosuppressive also. In Jurkat cells (immort...

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Publicado no:Biochem Biophys Rep
Main Authors: Fujita, Kazuki, Tanaka, Susumu, Iizumi, Kyoichi, Akiyama, Shuri, Uchida, Kaoru, Ogata, Makoto, Aoki, Daichi, Hosomi, Osamu, Kubohara, Yuzuru
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580327/
https://ncbi.nlm.nih.gov/pubmed/31431927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2019.100658
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