Partial Deletion of Glycoprotein B5R Enhances Vaccinia Virus Neutralization Escape while Preserving Oncolytic Function

Vaccinia virus (VV) has been utilized in oncolytic virotherapy, but it risks a host antiviral immune response. VV has an extracellular enveloped virus (EEV) form consisting of a normal virion covered with a host-derived outer membrane that enables its spread via circulation while evading host immune...

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Publicado en:Mol Ther Oncolytics
Main Authors: Nakatake, Motomu, Kurosaki, Hajime, Kuwano, Nozomi, Horita, Kosuke, Ito, Mai, Kono, Hiromichi, Okamura, Tomotaka, Hasegawa, Kosei, Yasutomi, Yasuhiro, Nakamura, Takafumi
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580015/
https://ncbi.nlm.nih.gov/pubmed/31236440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2019.05.003
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